SRU Biosystems said that Caliper Life Sciences will use SRU Biosystems' label-free Bind technology to offer new functional assays as part of its Discovery Alliances and Services.

The label-free Bind technology, developed by SRU Biosystems, provides researchers with a new ultra-high throughput screening and profiling system for cell-based and biochemical assays, the Company noted in a release. Bind technology for cell-based assays offers an orthogonal screening tool to access new hits and lead molecules that are not detected by other systems, including compounds that undergo G-protein switching, non-G protein coupled pathways, inverse and partial agonists, and receptor desensitization. The screening platform can be applied to both over-expressed and endogenous receptors, and can be used with low numbers of primary cells. The technology can also used for receptor profiling on native cells, due to the high sensitivity of the response. Lastly, the Bind technology provides a way to screen Gi-coupled GPCR targets and ion channels, which have been traditionally difficult to assess.